Ethyl-eicosapentaenoate (E-EPA) attenuates motor impairments and inflammation in the MPTP-probenecid mouse model of Parkinson's disease
Identifieur interne : 001525 ( Main/Exploration ); précédent : 001524; suivant : 001526Ethyl-eicosapentaenoate (E-EPA) attenuates motor impairments and inflammation in the MPTP-probenecid mouse model of Parkinson's disease
Auteurs : D. W. Luchtman [Canada] ; Q. Meng [Canada] ; C. Song [Canada, République populaire de Chine]Source :
- Behavioural brain research [ 0166-4328 ] ; 2012.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Parkinson's disease (PD) is a neurodegenerative disorder, characterized by hypokinesia, but also mood and cognitive disorders. Neuropathologically, PD involves loss of nigrostriatal dopamine (DA) and secondary non-dopaminergic abnormalities. Inflammation may contribute to PD pathogenesis, evident by increased production of pro-inflammatory cytokines. PD onset has been positively associated with dietary intake of omega-(n)-6 polyunsaturated fatty acids (PUFA). On the other hand, omega-(n)-3 PUFA may benefit PD. One of these n-3 PUFA, eicosapentaenoic acid (EPA), is a neuroprotective lipid with anti-inflammatory properties, but its neuroprotective effects in PD are unknown. Thus, we presently tested the hypothesis that EPA can protect against behavioral impairments, neurodegeneration and inflammation in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-probenecid (MPTP-P) mouse model of PD. MPTP-P injections caused hypokinesia in the rotorod and pole test, hyperactivity in the open field, and impaired mice on the cued version (procedural memory) of the Morris water maze. MPTP-P caused a loss of nigrostriatal DA and altered neurochemistry in the frontal cortex and hippocampus. Furthermore, striatal levels of pro-inflammatory cytokines were increased, while the brain n-3/n-6 lipid profile remained unaltered. Feeding mice a 0.8% ethyl-eicosapentaenoate (E-EPA) diet prior to MPTP-P injections increased brain EPA and docosapentaenoic acid (DPA) but not docosahexaenoic acid (DHA) or n-6 PUFA. The diet attenuated the hypokinesia induced by MPTP-P and ameliorated the procedural memory deficit. E-EPA also suppressed the production of pro-inflammatory cytokines. However, E-EPA did not prevent nigrostriatal DA loss. Based on this partial protective effect of E-EPA, further testing may be warranted.
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Song</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Biomedical Sciences, University of Prince Edward Island & National Institute for Nutrisciences and Health, 550 University Avenue</s1><s2>Charlottetown, PEI, C1A 4P3</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Charlottetown, PEI, C1A 4P3</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>National Engineering Institute for the Development of Endangered Medicinal Resources in Southwest China, Guangxi Botanic Garden of Medicinal Plants, 189 Changgang Road</s1><s2>530023, Nanning</s2><s3>CHN</s3><sZ>3 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>530023, Nanning</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0035551</idno><date when="2012">2012</date><idno type="stanalyst">PASCAL 12-0035551 INIST</idno><idno type="RBID">Pascal:12-0035551</idno><idno type="wicri:Area/PascalFrancis/Corpus">000242</idno><idno type="stanalyst">FRANCIS 12-0035551 INIST</idno><idno type="wicri:Area/PascalFrancis/Corpus">000263</idno><idno type="wicri:Area/PascalFrancis/Curation">000A10</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000164</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000164</idno><idno type="wicri:doubleKey">0166-4328:2012:Luchtman D:ethyl:eicosapentaenoate:e</idno><idno type="wicri:Area/Main/Merge">001578</idno><idno type="wicri:Area/Main/Curation">001525</idno><idno type="wicri:Area/Main/Exploration">001525</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Ethyl-eicosapentaenoate (E-EPA) attenuates motor impairments and inflammation in the MPTP-probenecid mouse model of Parkinson's disease</title><author><name sortKey="Luchtman, D W" sort="Luchtman, D W" uniqKey="Luchtman D" first="D. W." last="Luchtman">D. W. Luchtman</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Biomedical Sciences, University of Prince Edward Island & National Institute for Nutrisciences and Health, 550 University Avenue</s1><s2>Charlottetown, PEI, C1A 4P3</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Charlottetown, PEI, C1A 4P3</wicri:noRegion></affiliation></author><author><name sortKey="Meng, Q" sort="Meng, Q" uniqKey="Meng Q" first="Q." last="Meng">Q. Meng</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Biomedical Sciences, University of Prince Edward Island & National Institute for Nutrisciences and Health, 550 University Avenue</s1><s2>Charlottetown, PEI, C1A 4P3</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Charlottetown, PEI, C1A 4P3</wicri:noRegion></affiliation></author><author><name sortKey="Song, C" sort="Song, C" uniqKey="Song C" first="C." last="Song">C. Song</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Biomedical Sciences, University of Prince Edward Island & National Institute for Nutrisciences and Health, 550 University Avenue</s1><s2>Charlottetown, PEI, C1A 4P3</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Charlottetown, PEI, C1A 4P3</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>National Engineering Institute for the Development of Endangered Medicinal Resources in Southwest China, Guangxi Botanic Garden of Medicinal Plants, 189 Changgang Road</s1><s2>530023, Nanning</s2><s3>CHN</s3><sZ>3 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>530023, Nanning</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Behavioural brain research</title><title level="j" type="abbreviated">Behav. brain res.</title><idno type="ISSN">0166-4328</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Behavioural brain research</title><title level="j" type="abbreviated">Behav. brain res.</title><idno type="ISSN">0166-4328</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term><term>Animal model</term><term>Behavior</term><term>Inflammation</term><term>Motor system disorder</term><term>Mouse</term><term>Neurotoxin</term><term>Neurotransmitter</term><term>Parkinson disease</term><term>Probenecid</term><term>Uricosuric agent</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Trouble moteur</term><term>Inflammation</term><term>Neurotoxine</term><term>Probénécide</term><term>Modèle animal</term><term>Souris</term><term>Maladie de Parkinson</term><term>Comportement</term><term>Neurotransmetteur</term><term>Uricosurique</term><term>Animal</term><term>MPTP</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is a neurodegenerative disorder, characterized by hypokinesia, but also mood and cognitive disorders. Neuropathologically, PD involves loss of nigrostriatal dopamine (DA) and secondary non-dopaminergic abnormalities. Inflammation may contribute to PD pathogenesis, evident by increased production of pro-inflammatory cytokines. PD onset has been positively associated with dietary intake of omega-(n)-6 polyunsaturated fatty acids (PUFA). On the other hand, omega-(n)-3 PUFA may benefit PD. One of these n-3 PUFA, eicosapentaenoic acid (EPA), is a neuroprotective lipid with anti-inflammatory properties, but its neuroprotective effects in PD are unknown. Thus, we presently tested the hypothesis that EPA can protect against behavioral impairments, neurodegeneration and inflammation in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-probenecid (MPTP-P) mouse model of PD. MPTP-P injections caused hypokinesia in the rotorod and pole test, hyperactivity in the open field, and impaired mice on the cued version (procedural memory) of the Morris water maze. MPTP-P caused a loss of nigrostriatal DA and altered neurochemistry in the frontal cortex and hippocampus. Furthermore, striatal levels of pro-inflammatory cytokines were increased, while the brain n-3/n-6 lipid profile remained unaltered. Feeding mice a 0.8% ethyl-eicosapentaenoate (E-EPA) diet prior to MPTP-P injections increased brain EPA and docosapentaenoic acid (DPA) but not docosahexaenoic acid (DHA) or n-6 PUFA. The diet attenuated the hypokinesia induced by MPTP-P and ameliorated the procedural memory deficit. E-EPA also suppressed the production of pro-inflammatory cytokines. However, E-EPA did not prevent nigrostriatal DA loss. Based on this partial protective effect of E-EPA, further testing may be warranted.</div></front></TEI><affiliations><list><country><li>Canada</li><li>République populaire de Chine</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Luchtman, D W" sort="Luchtman, D W" uniqKey="Luchtman D" first="D. W." last="Luchtman">D. W. Luchtman</name></noRegion><name sortKey="Meng, Q" sort="Meng, Q" uniqKey="Meng Q" first="Q." last="Meng">Q. Meng</name><name sortKey="Song, C" sort="Song, C" uniqKey="Song C" first="C." last="Song">C. Song</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Song, C" sort="Song, C" uniqKey="Song C" first="C." last="Song">C. Song</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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